02994naa a2200313 a 450000100080000000500110000800800410001902000220006002200140008210000160009624502180011226000090033049000310033952019220037065000140229265300250230665300140233165300230234565300270236865300220239565300180241765300190243570000260245470000210248070000160250170000140251770000170253177301320254810604002019-11-13       2019    bl uuuu     u00u1 u    #d  a978-9974-38-436-1  a1688-92661 aMARESCA, S.  aEfecto de la restricción proteica de vacas durante la gestación tardía sobre el crecimiento posnatal, el metabolismo de glucosa - insulina y la concentración de IGF-1 de la descendencia.h[electronic resource]  c2019  a(INIA Serie Técnica; 252)  aABSTRACT The objective of this study was determine whether the amount of protein provided to cows during late gestation would affect postnatal growth and lead to changes on glucose, insulin and insulin-like growth factor concentrations. At 121 d prepartum, 68 multiparous Angus cows were blocked by BW and expected calving date and randomly assigned to low protein level (LP, 6% CP) or high protein level (HP, 12% CP) and were allotted in 12 pens per treatment. At calving, cows were managed together on improved pastures until weaning. Calves were weighed and body samples were taken at birth and each 30 d until weaning at 180 d of age. Body weight at birth on HP progeny tended to be great than LP progeny (P =0.06). At birth, calves from LP dams had greater head circumference (P < 0.01), heart girth (P =0.01) and cannon bone circumference (P =0.02). However, head circumference /birth BW ratio (P =0.04), heart girth /birth BW ratio (P =0.01), body length /birth BW ratio (P =0.05) and height /birth BW ratio (P =0.01) was greater on LP calves. Body mass index was greater in HP calves (P =0.04). No differences were found on BW of calves at weaning, adjusted 205 d BW and ADG during lactation (P > 0.10). Glucose concentrations were greater on LP calves than HP calves from birth to weaning (81.0 ± 1.5 vs. 76.4 ± 1.2 mg/dl; P < 0.001) without any change in insulin concentrations during preweaning growth (LP= 1.61 ± 0.04 ng/ml; HP= 1.61 ± 0.04 ng/ml; P > 0.10). Insulin- like growth factor concentrations were lower on LP calves at birth (P < 0.05) and similar to HP calves during postnatal growth (P > 0.10). These data demonstrate that low protein during late gestation in bovine dams may affect fetal growth with proportional increasing of head circumference and low body mass index. Level of protein compromised glucose regulation in early life and affected the IGF-I concentration of newborn calves.  aGESTACION  aCRECIMIENTO POSNATAL  aGESTATION  aGLUCOSE METABOLISM  aMETABOLISMO DE GLUCOSA  aPOST-NATAL GROWTH  aSUBNUTRICIÓN  aUNDERNUTRITION1 aLÓPEZ VALIENTE, S.O.1 aRODRÍGUEZ, A.M.1 aLONG, N. M.1 aPAVAN, E.1 aQUINTANS, G.  tIn: QUINTANS, G.; IEWDIUKOW, M. (Ed.). Primer Seminario Técnico de Programación Fetal. Montevideo (UY): INIA, 2019. p. 31-43.