02167naa a2200289 a 450000100080000000500110000800800410001902400450006010000200010524500900012526000090021552012750022465000140149965000330151365000190154665300170156565300280158265300350161065300150164570000170166070000180167770000180169570000210171370000180173470000180175277301070177010598512019-06-14       2019    bl uuuu     u00u1 u    #d7 a10.24070/bjvp.1983-0246.v12i1p19-232DOI1 aODRIOZOLA, E.R.  aSystemic granulomatous disease in dairy cattle from Argentina.h[electronic resource]  c2019  aAbstract: An outbreak of systemic granulomatous disease of unknown etiology was diagnosed in a dairy herd from Argentina. Eleven out of 211 cows manifested hyperthermia, depression, alopecia, pruritus, decreased milk production and death in most cases. During necropsy, multifocal petechial hemorrhages in glottis and vulva, white multifocal nodules in the liver and splenomegaly with subcapsular petechial hemorrhages were observed. Both kidneys were diffuse pale and enlarged. Systemic granulomatous hepatitis, myocarditis, pancreatitis and nephritis were observed. Water and food samples tested negative for Arsenic and T2 toxin, respectively. Fusarium equiseti was isolated from alfalfa hay samples. Vicia spp. was not consumed by the affected herd and no other cause of vetch-like disease was registered. Other causes of granulomatous lesions (Mycobacterium spp. and fungal infections) were discarded. The systemic granulomatous disease was suggestive of a type IV hypersensitivity reaction. Although the sensitizing agent was not determined, two components of the ration were suspected: cotton seed and bone ash. Both of them were introduced one month prior to the detection of the first affected cow and the disease resolved since they were removed from the diet.  aARGENTINA  aENFERMEDADES DE LOS ANIMALES  aGANADO LECHERO  aDAIRY CATTLE  aPLATAFORMA SALUD ANIMAL  aSYSTEMIC GRANULOMATOUS DISEASE  aVETCH-LIKE1 aDORSCH, M.A.1 aCAFFARENA, D.1 aMOREIRA, A.R.1 aFERNÁNDEZ, E.L.1 aMORRELL, E.L.1 aCANTÓN, G.J.  tBrazilian Journal of Veterinary Pathology, March 2019, Volume 12, Issue 1, Pages 19-23. [OPEN ACCESS].