02407naa a2200421 a 450000100080000000500110000800800410001902200140006002400340007410000240010824501270013226000090025950000720026852011510034065000090149165300340150065300100153465300250154465300330156965300200160265300280162265300280165065300270167865300170170565300110172265300170173370000150175070000150176570000140178070000190179470000130181370000200182670000150184670000150186170000190187670000180189577300720191310594092019-12-04       2018    bl uuuu     u00u1 u    #d  a1544-22177 a10.1177/03009858187981172DOI1 aMACÍAS-RIOSECO, M.  aFetal Pathology in an Aborted Holstein Fetus Infected With Bovine Parainfluenza Virus-3 Genotype A.h[electronic resource]  c2018  aArticle History:Date Created: 20180925 //Latest Revision: 20180924.  aAbstract: Bovine parainfluenza virus-3 (BPIV-3) is a recognized respiratory pathogen of cattle, and it has also been identified in aborted fetuses. However, little is known of this agent as a reproductive pathogen and detailed descriptions of fetal pathology on natural cases are lacking in the scientific literature. This article describes and illustrates lesions in a fetus spontaneously aborted by a firstcalving Holstein heifer, naturally infected with BPIV-3 genotype A, broadening the current knowledge on fetal pathology by this virus. Fetal autopsy revealed diffusely reddened, rubbery and unexpanded lungs. Histologically, there was necrotizing bronchiolitis/alveolitis with intraluminal fibrin exudate and syncytial cells in the bronchiolar/alveolar spaces, and non-suppurative peribronchiolitis and perivascular interstitial pneumonia. In the small intestine there was multifocal necrotizing cryptitis and occasional necrotic syncytial enterocytes. Intralesional and extralesional BPIV-3 antigen was detected by immunohistochemistry in the lung and small intestine, and BPIV-3a was identified in fetal tissues by RT-PCR and sequencing.  aFETO  aBOVINE PARAINFLUENZA VIRUS-3P  aFETUS  aIMMUNOHISTOCHEMISTRY  aPARAINFLUENZA VIRUS BOVINA-3  aPARAMYXOVIRIDAE  aPATOLOGÍA REPRODUCTIVA  aPLATAFORMA SALUD ANIMAL  aREPRODUCTIVE PATHOLOGY  aRESPIROVIRUS  aRT-PCR  aSALUD ANIMAL1 aMIRAZO ,S.1 aUZAL, F.A.1 aFRAGA, M.1 aSILVEIRA, C.S.1 aMAYA, L.1 aRIET-CORREA, F.1 aARBIZA, J.1 aCOLINA, R.1 aANDERSON ,M.L.1 aGIANNITTI, F.  tVeterinary Pathology [Vet Pathol], 2018 Sep 24, p. 300985818798117.