01903naa a2200349 a 450000100080000000500110000800800410001902200140006002400390007410000180011324501340013126000090026550003570027452006020063165300170123365300090125065300190125965300200127865300140129865300140131270000170132670000150134370000160135870000160137470000160139070000130140670000200141970000200143970000180145970000250147777300510150210593132018-11-28       2018    bl uuuu     u00u1 u    #d  a0041-01017 a10.1016/j.toxicon.2018.11.2912DOI1 aSALINAS, L.M.  aNeurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.h[electronic resource]  c2018  aArticle history: Received 16 September 2018 // Received in revised form 7 November 2018 // Accepted 9 November 2018 // Available online 14 November 2018. This work was partially supported by a grant from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria ( INIA , Spain), reference number E-RTA2013-00013-C04-04 (FEDER co-funded).  aABSTRACT. A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and α-galactosidase activities.  © 2018 Elsevier Ltd  aCALYSTEGINES  aGOAT  aIPOMOEA CARNEA  aIPOMOEA TRIFIDA  aNICARAGUA  aPOISONING1 aBALSEIRO, A.1 aJIRÓN, W.1 aPERALTA, A.1 aMUÑÓZ, D.1 aFAJARDO, J.1 aGAYO, E.1 aMARTÍNEZ, I.Z.1 aRIET-CORREA, F.1 aGARDNER, D.R.1 aGARCÍA MARÍN, J.F.  tToxicon, January 2019, Volume 157, Pages 8-11.