03310naa a2200385 a 450000100080000000500110000800800410001902200140006002400380007410000170011224500970012926000090022650001430023552020500037865300160242865300090244465300250245365300150247870000150249370000220250870000270253070000180255770000250257570000270260070000230262770000270265070000150267770000170269270000230270970000190273270000210275170000140277270000250278677301130281110590732021-02-12       2018    bl uuuu     u00u1 u    #d  a1871-14137 a10.1016/j.livsci.2018.09.0112DOI1 aAMORIM, S.T.  aGenomic study for maternal related traits in Santa Inês sheep breed.h[electronic resource]  c2018  aArticle history: Received 23 January 2018 // Revised 6 September 2018 // Accepted 11 September 2018 // Available online 20 September 2018.  aABSTRACT. The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with maternal related traits in Santa Inês sheep breed adapted to tropical climate. Phenotypic records for maternal efficiency (ME), metabolic maternal efficiency (MME), twin lambing (TL), adult weight (AW), metabolic adult weight (MAW), and body condition score (BCS) from 1,333 ewes from Santa Inês breed were used. A total of 576 animals were genotyped with the Ovine SNP12k BeadChip (Illumina, Inc.), that contains 12,785 bialleleic SNP markers. The variance components were estimated using a single trait animal model by single step genomic BLUP procedure. For AW, MAW, BCS, ME, MME and TL the mean values were 50.30 (±9.76), 19.2 (±2.33), 2.76 (±0.72), 34.6 (±15.95), 91.8 (±42.52), and 1.27 (±0.44) respectively. The heritabilities estimated were moderate for AW (0.32) and MAW (0.33) and low for BCS (0.04), ME (0.07), MME (0.08), and TL (0.10). A total of 7, 8, 13, 16, 19, and 09 candidate regions for ME, MME, TL, AW, MAW and BCS traits were identified respectively. AW and MAW had a total of 15 regions in common, while AW and BCS had a common region on chromosome 21. ME and MME had six candidate regions in common, and TL had no common regions with any other features. The maternal indicator traits have genetic variability to respond to selection in Santa Inês breed, and it would be expected higher genetic gain for ewe adult weight when compared to the others studied traits. Several candidate regions related to growth, reproduction, lactation and enviromental adaptability were identified in this study. These candidate regions would give support to identify and select animals with higher maternal efficiency and fitness, and consequently, increase the productivity of Santa Inês sheep. Moreover, the results of this study should help to understand the genetic and physiologic mechanism associated with maternal related traits in Santa Inês breed. © 2018 Elsevier B.V. All rights reserved.  aBODY WEIGHT  aGWAS  aMATTERNAL EFFICIENCY  aOVIS ARIES1 aKLUSKA, S.1 aPIATTO BERTON, M.1 aANTUNES DE LEMOS, M.V.1 aPERIPOLLI, E.1 aBONVINO STAFUZZA, N.1 aFERNÁNDEZ MARTÍN, J.1 aSAURA ÁLVAREZ, M.1 aVILLANUEVA GAVIÑA, B.1 aTORO, M.A.1 aBANCHERO, G.1 aSILVA OLIVEIRA, P.1 aGRIGOLETTO, L.1 aPEREIRA ELER, J.1 aBALDI, F.1 aSTERMAN FERRAZ, J.B.  tLivestock Science, November 2018, Volume 217, Pages 76-84. Doi: https://doi.org/10.1016/j.livsci.2018.09.011