02465naa a2200373 a 450000100080000000500110000800800410001902400360006010000200009624501910011626000090030750001030031652011960041965000280161565000110164365000200165465000190167465000210169365000100171465000220172465300290174665300300177565300270180565300220183265300280185470000190188270000120190170000190191370000180193270000150195070000210196570000200198677300850200610587232019-10-09       2018    bl uuuu     u00u1 u    #d7 a10.1590/1678-5150-PVB-52902DOI1 aSILVEIRA, A. M.  aEncefalopatia hepática secundária à intoxicação por Tephrosia cinerea em ovinos.(Hepatic encephalopathy secondary to poisoning by Tephrosia cinerea in sheep).h[electronic resource]  c2018  aArticle History: Recebido em 28 de abril de 2017.//Aceito para publicação em 17 de maio de 2017.  aAbstracts: In the semiarid region of northeastern Brazil, Tephrosia cinerea causes periacinar hepatic fibrosis in sheep with severe ascites and, occasionally, nervous signs. Sixteen sheep from six outbreaks of T. cinerea poisoning were studied. All sheep had histologic lesion of periacinar fibrosis and six showed, in the brain, vacuolization (spongy degeneration) of the white matter and junction between grey and white matter and presence of Alzheimer type II astrocytes in the grey matter. The disease was produced experimentally in two sheep, that presented porto-sistemic shunts and similar histologic lesions as those observed in the spontaneous cases. Immunohistochemistry revealed weak labelling with anti-GFAP antibodies suggesting a degenerative alteration of astrocytes with accumulation of dense bodies and reduction of the GFAP. There was strong labelling with anti-S100 antibodies suggesting cellular reactivity with proliferation of mitochondria and endoplasmatic reticulum. Such alterations are characteristic of the effects caused by ammonia on the astrocytes. It is concluded that in poisoning by T. cinerea nervous signs due to hepatic encephalopathy occur in some sheep.  aNERVOUS SYSTEM DISEASES  aOVINOS  aPLANT POISONING  aPLANTA TOXICAS  aPOISONOUS PLANTS  aSHEEP  aTEPHROSIA CINEREA  aENCEFALOPATÍA HEPÁTICA  aENVENENAMIENTO DE PLANTAS  aPLANTAS HEPATOTÓXICAS  aPLANTAS VENENOSAS  aPLATAFORMA SALUD ANIMAL1 aMOREIRA, E. C.1 aVAZ, F.1 aLORENZO, C. DE1 aDRIEMEIER, D.1 aFURLAN, F.1 aDANTAS, A. F. M.1 aRIET-CORREA, F.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 38, n. 4, p. 635-641, 2018.