02672naa a2200241 a 450000100080000000500110000800800410001902400430006010000260010324501240012926000090025350000980026252018740036065000240223465300140225865300140227265300180228665300190230465300210232370000160234470000160236077300540237610582252018-12-18       2018    bl uuuu     u00u1 u    #d7 a10.1016/j.anireprosci.2018.01.0172DOI1 aMORALES-PIÑEYRUA, J.  aEffects of parity on productive, reproductive, metabolic and hormonal responses of Holstein cow.h[electronic resource]  c2018  aHIstory article: Received date: 17-1-2017; Revised date: 29-1-2018; Accepted date: 31-1-2018.  aAbstract: The objective of this study was to determine the effects that parity may have on production, reproduction and the metabolic status of Holstein cows managed in a production system based on total mixed ration and pasture. Primiparous (n?=?22) and multiparous (n?=?24) cows from a dairy farm research station in Uruguay were used in a completely randomized design. Body weight (BW), body condition score (BCS) and backfat thickness (BFT) were recorded weekly from ?30 to 70 days postpartum. Milk production was measured daily, and milk composition was determined weekly. Resumption of postpartum ovarian activity and progesterone profiles were measured three times a week based on milk progesterone. Blood was collected to determine the levels of glucose, insulin-like growth factor I (IGF-1), insulin, non-esterified fatty acids (NEFA), ?-hydroxybutyrate (BHB), albumin, total protein and cholesterol. Milk production and components were lower for primiparous cows (p?<?0.01) than multiparous cows. Body weights were also lower in primiparous cows than in multiparous cows (p?<?0.05); however, BCS and BFT were greater (p?<?0.01) in primiparous cows than in multiparous cows. Primiparous cows had greater levels of glucose, insulin and IGF-1 and lower concentrations of NEFA and BHB (p?<?0.01) than multiparous cows. The intervals from calving to first ovulation were not affected by parity; however, primiparous cows showed less abnormal cycles (27.2%) than multiparous cows (50.0%) (p?<?0.01). The present study found that a feeding system based on TMR and pasture was sufficient to produce over 25?L of milk per day without extending their calving to first ovulation interval in primiparous and multiparous cows. However, multiparous cows showed a greater imbalance in metabolic and hormonal profiles than primiparous cows, causing abnormal ovarian activity.  aREPRODUCCION ANIMAL  aANESTROUS  aDAIRY COW  aENDOCRINOLOGY  aGRAZING SYSTEM  aPERI-PARTURITION1 aFARIÑA, S.1 aMENDOZA, A.  tAnimal Reproduction Sciencegv.191, p.9-21, 2018.