01644naa a2200205 a 450000100080000000500110000800800410001902000220006002400360008210000150011824500920013326000090022530000150023452010150024965300220126470000180128670000150130470000160131977301030133510567822019-10-04       2016    bl uuuu     u00u1 u    #d  a978-1-118-72840-67 a10.1002/9781118728291.ch132DOI1 aUZAL, F.A.  aDiseases produced by Clostridium perfringens type Dbchapter 13.h[electronic resource]  c2016  ap.157-172.  aSummary: Enterotoxemia caused by Clostridium perfringens type D, sometimes also called overeating disease or pulpy kidney disease, is a prevalent clostridial disease of sheep and goats. This chapter discusses the etiology, epidemiology and pathogenesis, clinical signs, diagnosis, prophylaxis, and treatment of diseases produced by C. perfringens type D. Type D enterotoxemia in sheep is a pure enterotoxemia, with no bacterial invasion of tissues, whereas in goats it may be a pure enterotoxemia, a localized enteric disease, or a combination of both. C. perfringens type D produces two typing toxins, namely alpha (CPA) and epsilon (ETX), although most type D isolates may express several other toxins. In sheep, a presumptive clinical diagnosis can be based on a history of access to heavy grain or concentrate feeding or abundant lush pasture, and clinical signs, especially in unvaccinated thriving lambs. Immunity in sheep is readily produced by vaccination, most vaccines being alum-adsorbed ETX toxoid.  aPATOLOGÍA ANIMAL1 aGIANNITTI, F.1 aFINNIE ,J.1 aGARCIA ,JP.  tIn: Uzal FA, Songer JG, Prescott JF, Popoff MR, eds. Clostridial Diseases of Animals. Wiley, 2016.