Fecha/hora: 11/05/2024 06:42:48

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	20/02/2024	
Fecha de la última actualización: 	20/02/2024	
Autoria: 	MACHADO, M.; MARTÍNEZ, R.; ANDRES, S.; SUMARAH, M.W.; RENAUD, J.B.; ARMIÉN, A.G.; BARROS, C.S.L.; RIET-CORREA, F.; MENCHACA, A.; SCHILD, C.	
Afiliación: 	MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAFAEL MARTÍNEZ, acuarembó, 45000, Uruguay, Tacuarembó, 45000, Uruguay; SOL ANDRES, CENUR Noreste, Universidad de la República, Tacuarembó, 45000, Uruguay; MARK W. SUMARAH, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; JUSTIN B. RENAUD, London Research and Development Centre, Agriculture & Agri-Food Canada, London, N5V 4T3, ON, Canada; ANÍBAL G. ARMIÉN, California Animal Health & Food Safety Laboratory System (CAHFS), School of Veterinary Medicine, University of California, Davis, 95616, CA, United States; CLAUDIO S. L. BARROS, Faculdade de Medicina Veterinária e Zootecnia (FMZV), Universidade Federal de Mato Grosso do Sul (, UFMS, Campo Grande 79070-900, Mato Grosso do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, Programa de Pós-Graduação em Ciência Animal nos Trópicos, Universidade Federal da Bahia (UFBA, Salvador, Bahia, 49170-110, Brazil; JOSE ALEJO MENCHACA BARBEITO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS SCHILD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; California Animal Health and Food Safety Laboratory System-San Bernardino Branch, University of California, San Bernardino, 92408, CA, United States.	
Título: 	Poisoning by Baccharis coridifolia in early-weaned beef calves: pathological study and new macrocyclic trichothecene identification.	
Año de publicación: 	2023	
Fuente/Imprenta: 	Toxins. 2023; 15(12):681. https://doi.org/10.3390/toxins15120681  --  OPEN ACCESS.	
ISSN: 	eISSN 2072-6651	
DOI: 	10.3390/toxins15120681	
Idioma: 	Inglés	
Notas: 	Article history: Submission received: 19 October 2023; Revised: 20 November 2023; Accepted: 27 November 2023; Published: 1 December 2023. -- Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxins15120681/s1 -- This article belongs to the Special Issue Toxins: 15th Anniversary (https://www.mdpi.com/journal/toxins/special_issues/U270856NY7 ). --
Reaxys Chemistry database information. Substances: Trichothecene, Roridin A. -- Funding: This research received no external funding. -- 
Acknowledgments: We thank Alejandra Custodio from Plataforma de Investigación en Salud Animal (PSA) of Instituto Nacional de Investigación Agropecuaria (INIA) for technical assistance with the histologic techniques, Ana Laura Vildoza for support with postmortem examination, Christina Heard (CAHFS) for the electron microscopy preparations, and Megan Kelman (AAFC) for technical support. Mizael Machado and Alejo Menchaca are researchers of the "Sistema Nacional de Investigadores" (SNI, ANII) of Uruguay. -- Document type: Article Gold Open Access, Article Green Open Access. -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).	
Contenido: 	ABSTRACT.- This study investigated two outbreaks of spontaneous poisoning by Baccharis coridifolia (Asteraceae) in early-weaned beef calves in Tacuarembó, Uruguay. A total of 34 affected calves showed signs of salivation, anorexia, apathy, marked dehydration, and diarrhea. Deaths occurred 36-72 h after consumption and mortality varied from 37.5% to 43.3% for outbreak 1 and outbreak 2, respectively. The main pathological findings include diffuse severe necrosis of the prestomachs and lymphoid tissues. Ultrastructurally, epithelial cells of the rumen showed swelling, lysis of the organelles, degradation of intercellular attachments, and degradation of the nuclear chromatin. Using LC-MS with diagnostic fragmentation filtering, 56 macrocyclic trichothecenes including glycosyl and malonyl conjugates were identified. The total concentration of macrocyclic trichothecenes, including conjugates, was estimated to be 1.2 ± 0.1 mg/g plant material. This is the first report of these malonyl-glucose conjugates from Baccharis coridifolia. © 2023 by the authors.	
Palabras-Clave: 	Baccharis; Mio-mio; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Poisonous plants; Ruminants; Toxicity; Uruguay.	
Categoría del tema: 	L01 Ganadería	
URL: 	https://www.mdpi.com/2072-6651/15/12/681/pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103814-1) - PXI - AP - DD - Toxins/2023 -  -  - DIS