Fecha/hora: 09/06/2024 04:43:19

Biblioteca(s): | INIA Las Brujas.
Fecha corriente: | 31/03/2021
Fecha de la última actualización: | 31/03/2021
Autoria: | ZHANG, X.; LOURENCO, D.; MISZTAL, I.; AGUILAR, I.; LEGARRA, A.
Afiliación: | XINYUE ZHANG, University of Georgia, Athens, Georgia, USA; DANIELA AL LOURENCO, University of Georgia, Athens, Georgia, USA; IGNACY MISZTAL, University of Georgia, Athens, Georgia, USA; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS LEGARRA, Institut National de la Recherche Agronomique (INRA), Castanet-Tolosan, France.
Título: | Weighted single-step genomic BLUP: an iterative approach for accurate calculation of GEBV and GWAS.
Complemento del título: | Volume Methods and Tools: Statistical and genomic tools for mapping QTL and genes (Posters), 681.
Año de publicación: | 2014
Fuente/Imprenta: | In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.681.
Idioma: | Inglés

Contenido:

ABSTRACT.
Three different procedures were implemented to calculate weights for a genomic relationship matrix to restrict the shrinkage along iterations of weighted single-step genomic BLUP (WssGBLUP).  The procedures as well as BayesC were tested with 3 simulated data sets. Prediction accuracy for WssGBLUP improved at 2nd or 3rd iteration by updating only the top number of SNP equal to 1 × or 3 × the number of QTL; accuracy increased after 3rd iteration and remained stable by using weights proportional to 2pi(1- pi)ui2+ constant. Except in the 5 QTL scenario, accuracies with all WssGBLUP procedures were higher than with BayesC. Noise in Manhattan plots was small with 5 and 100 QTL but large with 500 QTL.

Palabras-Clave: | GWAS; WssGBLUP.
Categoría del tema: | L10 Genética y mejoramiento animal
URL: | http://www.ainfo.inia.uy/digital/bitstream/item/15446/1/Zhang-et-al.-2014.-WCGALP.pdf
Registro original: | INIA Las Brujas (LB)
Ejemplares: | LB - (102601-1) - PXI - PC - DD - WCGALP/10/2014 -  -  - DIS