Fecha/hora: 06/06/2024 07:22:54

Biblioteca(s): 	INIA Las Brujas.	
Tipo de la producción científica: 	Artículos en Revistas Indexadas Internacionales	
Circulación/Nivel: 	A - 1	
Fecha corriente: 	24/10/2014	
Fecha de la última actualización: 	15/10/2019	
Autoria: 	ANAND-IVELL, R.; HIENDLEDER, S.; VIÑOLES, C.; MARTIN, G.B.; FITZSIMMONS, C.; EURICH, A.; HAFEN, B.; IVELL, R.	
Afiliación: 	RAVINDER ANAND-IVELL; STEFAN HIENDLEDER; CAROLINA VIÑOLES GIL, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay; GRAEME B. MARTIN; CAROLYN FITZSIMMONS; ANDREA EURICH; BETTINA HAFEN; RICHARD IVELL.	
Título: 	INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue.	
Año de publicación: 	2014	
Fuente/Imprenta: 	Plos ONE, 2014, v. 6, no.5, p. e19821.	
ISSN: 	1932-6203	
DOI: 	10.1371/journal.pone.0019821	
Idioma: 	Inglés	
Notas: 	Article history: Received December 20, 2010 / Accepted April 17, 2011 / Published May 16, 2011.	
Contenido: 	ABSTRACT,.

The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase of testicular descent, and in the adult male. In most female mammals, circulating levels are very low, corresponding to only a small production of INSL3 by the mature ovaries. Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea. We have developed a specific and sensitive immunoassay to measure ruminant INSL3 and show that, corresponding to the high ovarian gene expression, non-pregnant adult female sheep and cows have up to four times the levels observed in other female mammals. Significantly, this level declines during mid-pregnancy in cows carrying a female fetus, in which INSL3 is undetectable. However, in cows carrying a male fetus, circulating maternal INSL3 becomes elevated further, presumably due to the transplacental transfer of fetal INSL3 into the maternal circulation. Within male fetal blood, INSL3 is high in mid-pregnancy (day 153) corresponding to the first transabdominal phase of testicular descent, and shows a marked dependence on paternal genetics, with pure bred or hybrid male fetuses of Bos taurus (Angus) paternal genome having 30% higher INSL3 levels than those of Bos indicus (Brahman) paternity. Thus INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology.
© 2011 Anand-Ivell et al.	
Thesagro: 	MEJORAMIENTO GENÉTICO ANIMAL; RUMIANTES.	
Categoría del tema: 	L10 Genética y mejoramiento animal	
URL: 	http://www.ainfo.inia.uy/digital/bitstream/item/3644/1/Vinoles-C.-20121.-PLOS-One-v.65.pdf
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019821	
Registro original: 	INIA Las Brujas (LB)	
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