Fecha/hora: 09/06/2024 05:51:56

Biblioteca(s): 	INIA Las Brujas.	
Tipo de la producción científica: 	Artículos en Revistas Indexadas Internacionales	
Circulación/Nivel: 	Internacional - --	
Fecha corriente: 	16/03/2020	
Fecha de la última actualización: 	10/08/2020	
Autoria: 	AGUILAR, I.; FERNÁNDEZ, E.N.; BLASCO, A.; RAVAGNOLO, O.; LEGARRA, A.	
Afiliación: 	IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; EDUARDO N. FERNÁNDEZ, Cátedra de Mejora y Conservación de Recursos Genéticos e Instituto de Investigación sobre Producción Agropecuaria, Ambiente y Salud, Facultad de Ciencias Agrarias, UNLZ, Buenos Aires, Argentina; AGUSTÍN BLASCO, Institute for Animal Science and Technology, Universitat Politècnica de València, València, Spain; OLGA RAVAGNOLO GUMILA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS LEGARRA, UMR GenPhySE, INRA Toulouse, Castanet Tolosan, France.	
Título: 	Effects of ignoring inbreeding in model-based accuracy for BLUP and SSGBLUP.	
Año de publicación: 	2020	
Fuente/Imprenta: 	Journal of Animal Breeding and Genetics, 1 July 2020, Volume 137, Issue 4, pp. 356-364. Doi: https://doi.org/10.1111/jbg.12470	
ISSN: 	0931-2668	
DOI: 	10.1111/jbg.12470	
Idioma: 	Inglés	
Notas: 	Article history: Received: 22 August 2019 / Revised: 10 December 2019 / Accepted: 11 January 2020 / First published:20 February 2020
Corresponding author: Aguilar, I.; email:iaguilar@inia.org.uy
Funding information: FEDER; INRA; Universidad Nacional de Lomas de Zamora; European Unions' Horizon 2020 Research & Innovation Programme, Grant/Award Number: N°772787	
Contenido: 	ABSTRACT.
Model-based accuracy, defined as the theoretical correlation between true and estimated breeding value, can be obtained for each individual as a function of its prediction error variance (PEV) and inbreeding coefficient F, in BLUP, GBLUP and SSGBLUP genetic evaluations. However, for computational convenience, inbreeding is often ignored in two places. First, in the computation of reliability = 1-PEV/(1 + F). Second, in the set-up, using Henderson's rules, of the inverse of the pedigree-based relationship matrix A. Both approximations have an effect in the computation of model-based accuracy and result in wrong values. In this work, first we present a reminder of the theory and extend it to SSGBLUP. Second, we quantify the error of ignoring inbreeding with real data in three scenarios: BLUP evaluation and SSGBLUP in Uruguayan dairy cattle, and BLUP evaluations in a line of rabbit closed for >40 generations with steady increase of inbreeding up to an average of 0.30. We show that ignoring inbreeding in the set-up of the A-inverse is equivalent to assume that non-inbred animals are actually inbred. This results in an increase of apparent PEV that is negligible for dairy cattle but considerable for rabbit. Ignoring inbreeding in reliability = 1-PEV/(1 + F) leads to underestimation of reliability for BLUP evaluations, and this underestimation is very large for rabbit. For SSGBLUP in dairy cattle, it leads to both underestimation and overestimation of reliability, both for genotyped and non-genotyped animals. We strongly recommend to include inbreeding both in the set-up of A-inverse and in the computation of reliability from PEVs. 
© 2020 Blackwell Verlag GmbH	
Palabras-Clave: 	BREEDING; Genomic predictions; GENOMICS.	
Categoría del tema: 	L10 Genética y mejoramiento animal	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (102225-1) - PXI - AP - DD - PP/Jr.Animal Breed.&Genetics/2020 -  -  - DIS