Fecha/hora: 16/06/2024 05:44:56

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	13/06/2023	
Fecha de la última actualización: 	01/09/2023	
Autoria: 	GIANNITTI, F.; DORSCH, M.; FERNÁNDEZ-CIGANDA, S.; RABAZA, A.; VÁZQUEZ, S.; CÉSAR, C.; HURTADO, J.; GREIF, G.; RABENECK, D.; BHATNAGAR, J.; RITTER, J.	
Afiliación: 	FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MATÍAS ANDRÉS DORSCH, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SOFÍA FERNÁNDEZ-CIGANDA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANA VIRGINIA RABAZA MARTINEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SEBASTIÁN VÁZQUEZ, Private practice, Colonia del Sacramento, Uruguay; DEBORAH CÉSAR; JOAQUÍN HURTADO, Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay; GONZALO GREIF, Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay; DEMI B. RABENECK, Infectious Diseases Pathology Branch (IDPB), Centers for Disease Control and Prevention (CDC), Atlanta, GA; JULU BHATNAGAR, Infectious Diseases Pathology Branch (IDPB), Centers for Disease Control and Prevention (CDC), Atlanta, GA; JANA M. RITTER, Infectious Diseases Pathology Branch (IDPB), Centers for Disease Control and Prevention (CDC), Atlanta, GA.	
Título: 	Canine leproid granuloma caused by a member of the Mycobacterium tuberculosis complex. (Brief Report).	
Año de publicación: 	2023	
Fuente/Imprenta: 	Journal of Veterinary Diagnostic Investigation. 2023, Volume 35, Issue 4, pages 439-443. https://doi.org/10.1177/10406387231176816	
ISSN: 	1943-4936 (online).	
DOI: 	10.1177/10406387231176816	
Idioma: 	Inglés	
Notas: 	Article history: First published online May 19, 2023; Issue published July 2023. -- Corresponding author: Federico Giannitti, Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 50, km 11 (70006), La Estanzuela, Colonia, Uruguay. fgiannitti@inia.org.uy -- Funding: Funded by research grant PL_27 N-23398 from the Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay.	
Contenido: 	ABSTRACT.- Canine leproid granuloma (CLG) is a chronic form of dermatitis that has been associated with nontuberculous mycobacterial infections in Africa, Oceania, the Americas, and Europe. We report here a case of CLG associated with a member of the Mycobacterium tuberculosis complex (MTBC), which could be of public health concern. An 8-y-old pet dog developed 0.5-1-cm diameter, raised, firm, nonpruritic, alopecic, painless skin nodules on the external aspects of both pinnae. Histologic examination revealed severe pyogranulomatous dermatitis with intracellular Ziehl-Neelsen-positive bacilli that were immunoreactive by immunohistochemistry using a polyclonal primary antibody that recognizes tuberculous and nontuberculous Mycobacterium species. DNA extracted from formalin-fixed, paraffin-embedded skin sections was tested by a Mycobacterium genus-specific nested PCR assay targeting the 16S rRNA gene. BLAST sequence analysis of 214-bp and 178-bp amplicons showed 99.5% identity with members of the MTBC; however, the agent could not be identified at the species level. Although CLG has been associated traditionally with nontuberculous mycobacterial infections, the role of Mycobacterium spp. within the MTBC as a cause of this condition, and the role of dogs with CLG as possible sources of MTBC to other animals and humans, should not be disregarded given its zoonotic potential. © 2023 The Author(s).	
Palabras-Clave: 	Canine leproid granuloma; Dermatitis; Dogs; Mycobacterium tuberculosis complex; Pathology; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Pyogranuloma.	
Categoría del tema: 	L40 Estructura animal	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103535-1) - PXI - AP - DD - Jr. Vet. Diagn. Invest./2023 -  -  - DIS