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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
30/10/2024 |
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Actualizado : |
30/10/2024 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
IMELIO, J. A.; TRAJTENBERG, F.; MONDINO, S.; ZARANTONELLI, L.; VITRENKO, I.; LEMÉE, L.; COKELAER, T.; PICARDEAU, M.; BUSCHIAZZO, A. |
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Afiliación : |
JUAN ANDRÉS IMELIO, Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; FELIPE TRAJTENBERG, Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; SONIA MONDINO, Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; LETICIA ZARANTONELLI, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IAKOV VITRENKO, Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France; LAURE LEMÉE, Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France; THOMAS COKELAER, Plateforme Technologique Biomics, C2RT, Institut Pasteur, Université Paris Cité, Paris, France; Bioinformatics and Biostatistics Hub, Institut Pasteur, Paris, France; MATHIEU PICARDEAU, Biology of Spirochetes Unit, Institut Pasteur, Université Paris Cité, Paris, France; ALEJANDRO BUSCHIAZZO, Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; Dept of Microbiology, Institut Pasteur, Université Paris Cité, Paris, France. |
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Título : |
Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa. |
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Fecha de publicación : |
2024 |
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Fuente / Imprenta : |
PLoS ONE, 2024, Volume 19, Issue 9, e0311040. https://doi.org/10.1371/journal.pone.0311040 -- OPEN ACCESS. |
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ISSN : |
1932-6203 |
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DOI : |
10.1371/journal.pone.0311040 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 July 2024, Accepted 11 September 2024, Published 26 September 2024. -- Correspondence: Buschiazzo, A.; Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; email:alebus@pasteur.edu.uy -- Editor: Brian Stevenson, University of Kentucky College of Medicine, United States of America. -- Document type: Article, Gold Open Access. -- Publisher:
Public Library of Science. -- License: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ ). -- Funding: AB was supported by grants #FCE_1_2017_1_136291 (Agencia Nacional de Investigacion e Innovacion https://www.anii.org.uy/); and #PIU_761 Pasteur International Joint Research Unit IMiZA (Institut Pasteur/Institut Pasteur de Montevideo https://www.pasteur.fr/en/ & https://pasteur.uy/en/) MP was supported by grant #PIU_761 Pasteur International Joint Research Unit IMiZA (Institut Pasteur/Institut Pasteur de Montevideo https://www.pasteur.fr/en/ & https://pasteur.uy/en/) JAI had a PhD fellowship POS_NAC_2016_1_ 129903 (Agencia Nacional de Investigacion e Innovacion https://www.anii.org.uy/ ) TC was supported by grants #ANR-10-INBS-09 (Agence Nationale de la Recherche https://anr.fr/ en/) and IBISA (Infrastructures en Biologie, Sante et Agronomie https://www.ibisa.net/). |
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Contenido : |
ABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses.HemKR is a TCS present in both saprophytic and pathogenic Leptospira species, involved in the control of heme metabolism.However, the molecular means by which HemKR is switched on/off in a signal-dependent way, are still unknown.Moreover, a comprehensive list of HemKR-regulated genes, potentially overlapped with iron-responsive targets, is also missing. © 2024 Imelio et al. |
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Palabras claves : |
Bacterial Proteins; Leptospira; RNA extraction; RNA sequence; UNIDAD MIXTA PASTEUR + INIA. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17906/1/journal.pone.0311040.pdf
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Marc : |
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008 2024 bl uuuu u00u1 u #d
022 $a1932-6203
024 7 $a10.1371/journal.pone.0311040$2DOI
100 1 $aIMELIO, J. A.
245 $aSignal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa.$h[electronic resource]
260 $c2024
500 $aArticle history: Received 12 July 2024, Accepted 11 September 2024, Published 26 September 2024. -- Correspondence: Buschiazzo, A.; Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay; email:alebus@pasteur.edu.uy -- Editor: Brian Stevenson, University of Kentucky College of Medicine, United States of America. -- Document type: Article, Gold Open Access. -- Publisher: Public Library of Science. -- License: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ ). -- Funding: AB was supported by grants #FCE_1_2017_1_136291 (Agencia Nacional de Investigacion e Innovacion https://www.anii.org.uy/); and #PIU_761 Pasteur International Joint Research Unit IMiZA (Institut Pasteur/Institut Pasteur de Montevideo https://www.pasteur.fr/en/ & https://pasteur.uy/en/) MP was supported by grant #PIU_761 Pasteur International Joint Research Unit IMiZA (Institut Pasteur/Institut Pasteur de Montevideo https://www.pasteur.fr/en/ & https://pasteur.uy/en/) JAI had a PhD fellowship POS_NAC_2016_1_ 129903 (Agencia Nacional de Investigacion e Innovacion https://www.anii.org.uy/ ) TC was supported by grants #ANR-10-INBS-09 (Agence Nationale de la Recherche https://anr.fr/ en/) and IBISA (Infrastructures en Biologie, Sante et Agronomie https://www.ibisa.net/).
520 $aABSTRACT.- Heme and iron metabolic pathways are highly intertwined, both compounds being essential for key biological processes, yet becoming toxic if overabundant.Their concentrations are exquisitely regulated, including via dedicated two-component systems (TCSs) that sense signals and regulate adaptive responses.HemKR is a TCS present in both saprophytic and pathogenic Leptospira species, involved in the control of heme metabolism.However, the molecular means by which HemKR is switched on/off in a signal-dependent way, are still unknown.Moreover, a comprehensive list of HemKR-regulated genes, potentially overlapped with iron-responsive targets, is also missing. © 2024 Imelio et al.
653 $aBacterial Proteins
653 $aLeptospira
653 $aRNA extraction
653 $aRNA sequence
653 $aUNIDAD MIXTA PASTEUR + INIA
700 1 $aTRAJTENBERG, F.
700 1 $aMONDINO, S.
700 1 $aZARANTONELLI, L.
700 1 $aVITRENKO, I.
700 1 $aLEMÉE, L.
700 1 $aCOKELAER, T.
700 1 $aPICARDEAU, M.
700 1 $aBUSCHIAZZO, A.
773 $tPLoS ONE, 2024, Volume 19, Issue 9, e0311040. https://doi.org/10.1371/journal.pone.0311040 -- OPEN ACCESS.
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INIA Las Brujas (LB) |
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| 2. |  | IMELIO, J. A.; TRAJTENBERG, F.; MONDINO, S.; ZARANTONELLI, L.; VITRENKO, I.; LEMÉE, L.; COKELAER, T.; PICARDEAU, M.; BUSCHIAZZO, A. Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa. PLoS ONE, 2024, Volume 19, Issue 9, e0311040. https://doi.org/10.1371/journal.pone.0311040 -- OPEN ACCESS. Article history: Received 12 July 2024, Accepted 11 September 2024, Published 26 September 2024. -- Correspondence: Buschiazzo, A.; Laboratory of Molecular & Structural Microbiology, Institut Pasteur de Montevideo, Montevideo, Uruguay;...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 2 | |
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