Fecha/hora: 16/06/2024 06:25:20

Biblioteca(s): 	INIA La Estanzuela.	
Fecha corriente: 	16/02/2017	
Fecha de la última actualización: 	24/06/2021	
Autoria: 	PHAN, T.G; GIANNITTI, F.; ROSSOW,S.; MARTHALER,D.; KNUTSON, T.; LI, L.; DENG, X.; RESENDE, T.; VANNUCCI, F.; DELWART, E.	
Afiliación: 	FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.	
Título: 	Detection of a novel circovirus PCV3 in pigs with cardiac and multi-systemic inflammation.	
Año de publicación: 	2016	
Fuente/Imprenta: 	Virology Journal, 2016 v.13 n. 1. p. 184	
DOI: 	10.1186/s12985-016-0642-z	
Idioma: 	Inglés	
Notas: 	OPEN ACCESS	
Contenido: 	Abstract.
Background: Porcine circovirus 2 causes different clinical syndromes resulting in a significant economic loss in the
pork industry. Three pigs with unexplained cardiac and multi-organ inflammation that tested negative for PCV2 and
other known porcine pathogens were further analyzed.
Methods: Histology was used to identify microscopic lesions in multiple tissues. Metagenomics was used to detect
viral sequences in tissue homogenates. In situ hybridization was used to detect viral RNA expression in cardiac tissue.
Results: In all three cases we characterized the genome of a new circovirus we called PCV3 with a replicase and capsid
proteins showing 55 and 35 % identities to the genetically-closest proteins from a bat-feces associated circovirus and
were even more distant to those of porcine circovirus 1 and 2. Common microscopic lesions included non-suppurative
myocarditis and/or cardiac arteriolitis. Viral mRNA was detected intralesionally in cardiac cells. Deep sequencing in
tissues also revealed the presence of porcine astrovirus 4 in all three animals as well as rotavirus A, porcine cytomegalovirus
and porcine hemagglutinating encephalomyelitis virus in individual cases.
Conclusion: The pathogenicity and molecular epidemiology of this new circovirus, alone or in the context of
co-infections, warrants further investigations.	
Palabras-Clave: 	ARTERIOLITIS; ARTEROLITIS; CIRCOVIRUS; METAGENÓMICA; METAGENOMICS; MIOCARDITIS; PIG; VASCULITIS.	
Thesagro: 	CERDO.	
Categoría del tema: 	L73 Enfermedades de los animales	
URL: 	http://www.ainfo.inia.uy/digital/bitstream/item/6477/1/Virology-Journal-2016-13.p.184-Phan-et-al..pdf	
Registro original: 	INIA La Estanzuela (LE)	
Ejemplares: 	LE - (101883-1) - PXI - AP - DD - LE-PP/VJ/2016/13/1/184/Phan et al. -  -  - DIS