Fecha/hora: 08/06/2024 01:24:48

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	17/10/2014	
Fecha de la última actualización: 	03/10/2019	
Autoria: 	KALPOKAS, I.; PERDIGON, F.; RIVERO, R.; TALMON, M.; SARTORE, I.; VIÑOLES, C.	
Afiliación: 	CAROLINA VIÑOLES GIL, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay.	
Título: 	Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares.	
Año de publicación: 	2010	
Fuente/Imprenta: 	Acta Veterinaria Scandinavica, 2010, v.52, No.1, p.66-73. OPEN ACCESS	
ISSN: 	0044-605X	
DOI: 	10.1186/1751-0147-52-66	
Idioma: 	Inglés	
Notas: 	Article history: Received: 15 August 2010 / Accepted: 16 December 2010 / Published: 16 December 2010.	
Contenido: 	BACKGROUND.

Intrauterine infusions have been widely used for the treatment of endometritis in the mare. Nevertheless, their consequences on endocrine and endometrial molecular aspects are unknown. We studied the effect of a 1% povidone-iodine solution intrauterine infusion on progesterone levels, endometrial histology and estrogen (ER&#945;) and progesterone (PR) receptor distribution by immunohistochemistry.Methods: Fourteen healthy mares were used in this study. Estruses were synchronized and seven mares were treated with intrauterine infusions at days 0 and 2 post ovulation of two consecutive estrous cycles. Uterine biopsy samples were taken on days 6 and 15 post ovulation.Results: The treatment did not induce an inflammatory response indicating endometritis, neither affected the ER&#945;. However, it reduced the percentage of PR positive cells (PPC) on day 6 (deep glandular epithelium, control: 95.7 vs. infused: 61.5, P < 0.05). Treated mares tended to have lower progesterone levels on day 2 (3.9 ng/ml vs. 6.6 ng/ml, P = 0.07), and higher levels on day 15 compared with controls (4.4 ng/ml vs. 1.3 ng/ml, P = 0.07).Conclusion: a 1% povidone-iodine infusion during days 0 and 2 post ovulation in healthy mares did not induce histological changes indicating endometritis, but altered progesterone concentrations and reduced the expression of endometrial PR at day 6 without affecting the ER&#945;. These changes could reduce embryo survival. 
© 2010 Kalpokas et al; licensee BioMed Central Ltd.	
Palabras-Clave: 	ANIMAL DISEASE.	
Thesagro: 	AGENTES INFECCIOSOS; ENDOMETRITIS; ENFERMEDADES DE LOS ANIMALES.	
Categoría del tema: 	L73 Enfermedades de los animales	
URL: 	http://www.actavetscand.com/content/52/1/66
http://www.ainfo.inia.uy/digital/bitstream/item/3575/1/Vinoles-C.-2010.-Acta-Veterinaria-Scandinavica-v.521-p.66.pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (100203-1) - PXI - AP - DD - PP/ACTA VETERINARIA SCAND./2010 -  -  - DIS