Fecha/hora: 23/05/2024 00:52:31

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	11/04/2017	
Fecha de la última actualización: 	09/10/2019	
Autoria: 	DALLA RIZZA, M.; DIAZ, P.; NARANCIO, R.; CABRERA, A.; FERREIRA, F.	
Afiliación: 	MARCO DALLA RIZZA VILARO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAOLA ALEXANDRA DIAZ DELLAVALLE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAFAEL NARANCIO FERES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDREA CECILIA CABRERA BARRIOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FERNANDO FERREIRA, Universidad de la República (UdelaR)/ Facultad de Química.	
Título: 	Biomolecules as host defense weapons against microbial pathogens. (Review)	
Año de publicación: 	2008	
Fuente/Imprenta: 	Recent Patents on DNA and Gene Sequences, 2008, v.2, no.2, p.82-96.	
ISSN: 	1872-2156	
DOI: 	10.2174/187221508784534186	
Idioma: 	Inglés	
Notas: 	Article history: Received: April 21, 2008 / Accepted: April 29, 2008 / Revised: April 29, 2008.	
Contenido: 	ABSTRACT.

Antimicrobial peptides have been considered a new source of biomolecules in several fields of research/innovative applications: they would adjust to an ideal behavior seeking to overcome clinician, microbiological, human-animal-plant-environmental concerns. Antimicrobial peptides can be considered as ancient weapons found in living organisms suggesting they have played a fundamental role in his successful co-evolution with pathogens. Acting on microorganism membrane or having intracellular targets, they can also act as effectors of the innate immune response resulting on non-specific mechanisms of action. Two elements have speeded the research on pathogen control alternatives: a verified increase of antibiotic resistance and the relevance of finding amenable environmental compounds in plant health. As a result of its importance, great efforts have been accomplished to find, characterize, combine and synthesize effective antimicrobial peptides. This review intends to emphasize the generation of biomolecules, whether native or synthetic analogues, that have been matter of recent patents. Development of biomolecules suitable for therapeutic scopes and agricultural use have several challenges such as intrinsic toxicity, in vivo stability and suitable formulation contemplating the cost of production. Thus, biotechnological procedures using microbial systems or transgenic crops as plant factories might help to solve these challenges. 

© 2008 Bentham Science Publishers Ltd.	
Palabras-Clave: 	ANTIMICROBIAL; BIOCONTROL AGENTS; MODES OF ACTION; PEPTIDES.	
Thesagro: 	AGENTES DE CONTROL BIOLOGICO; ANTIMICROBIANOS; PEPTIDOS.	
Categoría del tema: 	--	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (101339-1) - PXI - AP - DD - PP/RECENT PATENTS on DNA/2008 -  -  - DIS