Fecha/hora: 31/05/2024 21:29:37

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	08/03/2023	
Fecha de la última actualización: 	15/03/2023	
Autoria: 	RAMOS, Z.; GARRICK , D. J.; BLAIR, H. T.; VERA, B.; CIAPPESONI, G.; KENYON, P. R.	
Afiliación: 	ZULLY MARGOT RAMOS ALVEZ, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; DORIAN J. GARRICK, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; HUGH T. BLAIR, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAUL R. KENYON, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand.	
Título: 	Genomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep.	
Año de publicación: 	2023	
Fuente/Imprenta: 	Genes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167	
ISSN: 	2073-4425	
DOI: 	10.3390/genes14010167	
Idioma: 	Inglés	
Notas: 	Article history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz  -- Academic Editor: Qiuyue Liu  -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- FUNDING: his research was funded by the Regional Consortium for Innovation in Ultrafine Wool (CRILU), the European Union?s Horizon 2020 research and innovation program under the grant agreement n°772787 (Smarter) and the National Institute of Agricultural Research of Uruguay (INIA_CL_38: Rumiar). This study was supported by two Ph.D. scholarships (from the National Agency for Investigation and Innovation of Uruguay, ANII, and Massey University, New Zealand), awarded to Zully Ramos. -- LICENSSE: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). -- 
Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/genes14010167/s1, Table S1: Enrichment analysis.	
Contenido: 	The aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE > 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes. Copyright: © 2023 by the authors	
Palabras-Clave: 	Body condition score; Fiber diameter; Gene; GWAS; Reproduction; Sheep.	
Categoría del tema: 	L10 Genética y mejoramiento animal	
URL: 	https://www.mdpi.com/2073-4425/14/1/167/pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103318-1) - PXI - AP - DD - Genes/2023 -  -  - DIS