Fecha/hora: 16/06/2024 02:21:37

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	11/12/2018	
Fecha de la última actualización: 	06/02/2019	
Autoria: 	MOTA, R. R.; LOPES, P. S.; TEMPELMAN, R. J.; SILVA, F. F.; AGUILAR, I.; GOMES, C. C. G.; CARDOSO, F. F.	
Afiliación: 	R. R. MOTA, Animal Science Department, Federal University of Viçosa, Brazil; P. S. LOPES, Animal Science Department, Federal University of Viçosa, Viçosa, Brazil; R. J. TEMPELMAN, Animal Science Department, Michigan State University, United States; F. F. SILVA, Animal Science Department, Federal University of Viçosa, Brazil; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; C. C. G. GOMES, Embrapa South Livestock, Brazil; F. F. CARDOSO, eAnimal Science Department, Federal University of Pelotas, Brazil.	
Título: 	Genome-enabled prediction for tick resistance in Hereford and Braford beef cattle via reaction norm models.	
Año de publicación: 	2016	
Fuente/Imprenta: 	Journal of Animal Science, May 2016, Volume 94, Issue 5, Pages 1834 - 1843.	
ISSN: 	0021-8812	
DOI: 	10.2527/jas.2015-0194	
Idioma: 	Inglés	
Notas: 	Article history: Received December 11, 2015. // Accepted March 10, 2016.	
Contenido: 	ABSTRACT.
Very few studies have been conducted to infer genotype × environment interaction (G×E) based in genomic prediction models using SNP markers. Therefore, our main objective was to compare a conventional genomic-based single-step model (HBLUP) with its reaction norm model extension (genomic 1-step linear reaction norm model [HLRNM]) to provide EBV for tick resistance as well as to compare predictive performance of these models with counterpart models that ignore SNP marker information, that is, a linear animal model (ABLUP) and its reaction norm extension (1-step linear reaction norm model [ALRNM]). Phenotypes included 10,673 tick counts on 4,363 Hereford and Braford animals, of which 3,591 were genotyped. Using the deviance information criterion for model choice, ABLUP and HBLUP seemed to be poorer fitting in comparison with their respective genomic model extensions. The HLRNM estimated lower average and reaction norm genetic variability compared with the ALRNM, whereas ABLUP and HBLUP seemed to be poorer fitting in comparison with their respective genomic reaction norm model extensions. Heritability and repeatability estimates varied along the environmental gradient (EG) and the genetic correlations were remarkably low between high and low EG, indicating the presence of G×E for tick resistance in these populations. Based on 5-fold K-means partitioning, mean cross-validation estimates with their respective SE of predictive accuracy were 0.66 (SE 0.02), 0.67 (SE 0.02), 0.67 (SE 0.02), and 0.66 (SE 0.02) for ABLUP, HBLUP, HLRNM, and ALRNM, respectively. For 5-fold random partitioning, HLRNM (0.71 ± 0.01) was statistically different from ABLUP (0.67 ± 0.01). However, no statistical significance was reported when considering HBLUP (0.70 ± 0.01) and ALRNM (0.70 ± 0.01). Our results suggest that SNP marker information does not lead to higher prediction accuracies in reaction norm models. Furthermore, these accuracies decreased as the tick infestation level increased and as the relationship between animals in training and validation data sets decreased. 
© 2016 American Society of Animal Science. All rights reserved.	
Palabras-Clave: 	ACCURACY; CROSS-VALIDATION; GENETIC CORRELATION; HERITABILITY.	
Categoría del tema: 	--	
URL: 	http://www.ainfo.inia.uy/digital/bitstream/item/12162/1/mota2016.pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (101746-1) - PXI - AP - DD - PP/JR. ANIMAL SCIENCE/2016 -  -  - DIS