Fecha/hora: 11/06/2024 15:56:45

Biblioteca(s): 	INIA La Estanzuela; INIA Las Brujas.	
Fecha corriente: 	20/05/2022	
Fecha de la última actualización: 	30/11/2022	
Autoria: 	BERTON, M. P.; DA SILVA, ROSIANE PEREIRA; BANCHERO, G.; MOURÃO, G. B.; FERRAZ, J. B. S.; SCHENKEL, F. S.; BALDI, F.	
Afiliación: 	MARIANA PIATTO BERTON, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil; ROSIANE PEREIRA DA SILVA, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, Brazil; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GERSON BARRETO MOURÃO, Departamento de Zootecnia, Escola Superior de Agricultura “Luiz de Queiroz”, Universidade de São Paulo/ESALQ, Piracicaba, Brazil; JOSE BENTO STERMAN FERRAZ, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, Brazil; FLAVIO SCHRAMM SCHENKEL, Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada; FERNANDO BALDI, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil.	
Título: 	Genomic integration to identify molecular biomarkers associated with indicator traits of gastrointestinal nematode resistance in sheep.	
Año de publicación: 	2022	
Fuente/Imprenta: 	Journal of Animal Breeding and Genetics, 2022, Volume 139, Issue 5, pages 502-516. doi: https://doi.org/10.1111/jbg.12682	
ISSN: 	0931-2668	
DOI: 	10.1111/jbg.12682	
Idioma: 	Inglés	
Notas: 	Article history: Received 14 June 2021; Accepted 21 April 2022; First published 09 May 2022; Publisched online September 2022. -- Corresponding author:  Berton, M.P.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil; email:mapberton@gmail.com --	
Contenido: 	ABSTRACT.- This study aimed to integrate GWAS and structural variants to propose possible molecular biomarkers related to gastrointestinal nematode resistance traits in Santa Inês sheep. The phenotypic records FAMACHA, haematocrit, white blood cell count, red blood cell count, haemoglobin, platelets and egg counts per gram of faeces were collected from 700 naturally infected animals, belonging to four Brazilian flocks. A total of 576 animals were genotyped using the Ovine SNP12k BeadChip and were imputed using a reference population with Ovine SNP50 BeadChip. The GWAS approaches were based on SNPs, haplotypes, CNVs and ROH. The overlapping between the significant genomic regions detected from all approaches was investigated, and the results were integrated using a network analysis. Genes related to the immune system were found, such as ABCB1, IL6, WNT5A and IRF5. Genomic regions containing candidate genes and metabolic pathways involved in immune responses, inflammatory processes and immune cells affecting parasite resistance traits were identified. The genomic regions, biological processes and candidate genes uncovered could lead to biomarkers for selecting more resilient sheep and improving herd welfare and productivity. The results obtained are the start point to identify molecular biomarkers related to indicator traits of gastrointestinal nematode resistance in Santa Inês sheep. © 2022 Wiley-VCH GmbH.	
Palabras-Clave: 	Copy number variant; GWAS; GWAS - Genome-wide association study; Haplotype; Integration analyses; Run of homozygosity; System biology.	
Thesagro: 	OVEJA.	
Categoría del tema: 	--
L10 Genética y mejoramiento animal	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103078-1) - PXI - AP - DD - Jr. Animal Breeding & Genetics/2022 -  -  - DIS
LE - (103572-1) - PXI - AP - DD - PP/JABG/2022 -  -  - DIS