Fecha/hora: 15/06/2024 21:49:45

Biblioteca(s): | INIA Las Brujas.
Fecha corriente: | 31/03/2021
Fecha de la última actualización: | 31/03/2021
Autoria: | FORNERIS, N. S.; LEGARRA, A.; VITEZICA, Z. G.; TSURUTA, S.; AGUILAR, I.; CANTET, R.J.C.; MISZTAL, I.
Afiliación: | NATALIA S. FORNERIS, Department of Animal Science, University of Buenos Aires, Argentina; ANDRÉS LEGARRA, INRA, Castanet-Tolosan, France; ZULMA G VITEZICA, INRA, Castanet-Tolosan, France; SHOGO TSURUTA, University of Georgia, Athens, GA, USA; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RODOLFO J.C. CANTET, Department of Animal Science, University of Buenos Aires, Argentina; # CONICET, Argentina.; IGNACY MISZTAL, University of Georgia, Athens, GA, USA.
Título: | Quality control of genotypes using heritability estimates of gene content.
Complemento del título: | Volume Genetic Improvement Programs: Selection using molecular information (Posters), 471.
Año de publicación: | 2014
Fuente/Imprenta: | In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 10., Vancouver, BC, Canada, August 17-22, 2014. p.471.
Idioma: | Inglés

Contenido:

ABSTRACT.
Quality control filtering of single nucleotide polymorphisms (SNP) is a key step when analyzing genomic data. Here, we present a practical method to identify poorly genotyped SNPs by detecting those for which gene content deviates from the pedigree-based expectation. This can be achieved by estimating the heritability of gene content at each marker, defined as the number of copies of a particular reference allele in a genotype of an animal (0, 1 or 2). The method uses Restricted Maximum Likelihood (REML) to estimate heritability of gene content at each SNP and also builds a likelihood ratio test statistic to test for zero error variance in genotyping. The proposed method is illustrated with a real dataset with genotypes from Illumina PorcineSNP60 chip.

Palabras-Clave: | Gene Content; Heritability; Likelihood Ratio; Quality Control.
Categoría del tema: | L10 Genética y mejoramiento animal
URL: | http://www.ainfo.inia.uy/digital/bitstream/item/15444/1/Forneris-et-al.-2014.-WCGALP.pdf
Registro original: | INIA Las Brujas (LB)
Ejemplares: | LB - (102599-1) - PXI - PC - DD - WCGALP/10/2014 -  -  - DIS