Fecha/hora: 15/06/2024 16:41:55

Biblioteca(s): | INIA Las Brujas.
Fecha corriente: | 07/10/2014
Fecha de la última actualización: | 09/10/2019
Autoria: | VITEZICA, Z.G.; AGUILAR, I.; MISZTAL, I.; LEGARRA, A.
Afiliación: | IGNACIO AGUILAR GARCIA, Instituto Nacional de Investigación Agropecuaria (INIA), Uruguay.
Título: | Bias in genomic predictions for populations under selection.
Año de publicación: | 2011
Fuente/Imprenta: | Genetics Research, 2011, v.93 no.5, p.357-366.
ISSN: | 0016-6723
DOI: | 10.1017/S001667231100022X
Idioma: | Inglés
Notas: | Article history: Received 27 January 2011 /  Revised 27 March 2011 / Published online 18 July 2011.

Contenido:

ABSTRACT.

Prediction of genetic merit or disease risk using genetic marker information is becoming a common practice for selection of livestock and plant species. For the successful application of genome-wide marker-assisted selection (GWMAS), genomic predictions should be accurate and unbiased. The effect of selection on bias and accuracy of genomic predictions was studied in two simulated animal populations under weak or strong selection and with several heritabilities. Prediction of genetic values was by best-linear unbiased prediction (BLUP) using data either from relatives summarized in pseudodata for genotyped individuals (multiple-step method) or using all available data jointly (single-step method). The single-step method combined genomic- and pedigree-based relationship matrices. Predictions by the multiple-step method were biased. Predictions by a single-step method were less biased and more accurate but under strong selection were less accurate. When genomic relationships were shifted by a constant, the single-step method was unbiased and the most accurate. The value of that constant, which adjusts for non-random selection of genotyped individuals, can be derived analytically. 
© 2011 Cambridge University Press.

Thesagro: | DETECCIÓN DE QTLS; MARCADORES GENÉTICOS; MEJORAMIENTO GENÉTICO ANIMAL.
Categoría del tema: | L10 Genética y mejoramiento animal
Registro original: | INIA Las Brujas (LB)
Ejemplares: | LB - (100173-1) - PXI - AP - DD - PP/GENET.RESEARCH/2011 -  -  - DIS