Fecha/hora: 03/06/2024 09:52:00

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	23/12/2021	
Fecha de la última actualización: 	23/12/2021	
Autoria: 	JORGE-SMEDING, E.; CARRIQUIRY, M.; CANTALAPIEDRA-HIJAR, G.; MENDOZA, A.; ASTESSIANO, A.L.	
Afiliación: 	EZEQUIEL JORGE-SMEDING, Departamento de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Montevideo, Uruguay.; MARIANA CARRIQUIRY, Departamento de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Montevideo, Uruguay.; GONZALO CANTALAPIEDRA-HIJAR, INRAE, Université Clermont Auvergne, VetAgro Sup, UMRH, Saint-Genès-Champanelle, France.; ALEJANDRO FRANCISCO MENDOZA AGUIAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANA LAURA ASTESSIANO, Departamento de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Montevideo, Uruguay.	
Título: 	Plasma concentrations of branched-chain amino acids differ with Holstein genetic strain in pasture-based dairy systems.
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Año de publicación: 	2021	
Fuente/Imprenta: 	Scientific Reports, December 2021, Volume 11, Issue 1, Article number 22414. Open Access. doi: https://doi.org/10.1038/s41598-021-01564-0	
ISSN: 	2045-2322	
DOI: 	10.1038/s41598-021-01564-0	
Idioma: 	Inglés	
Notas: 	Article history: Received 11 May 2021; Accepted 09 September 2021; Published 17 November 2021.
Correspondence author:   Astessiano, A.L.; Departamento de Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Av. Garzón 780, Montevideo, Uruguay; email:lauaste@gmail.com	
Contenido: 	ABSTRACT - 
In pasture-based systems, there are nutritional and climatic challenges exacerbated across lactation; thus, dairy cows require an enhanced adaptive capacity compared with cows in confined systems. We aimed to evaluate the effect of lactation stage (21 vs. 180 days in milk, DIM) and Holstein genetic strain (North American Holstein, NAH, n = 8; New Zealand Holstein, NZH, n = 8) on metabolic adaptations of grazing dairy cows through plasma metabolomic profiling and its association with classical metabolites. Although 67 metabolites were affected (FDR < 0.05) by DIM, no metabolite was observed to differ between genetic strains while only alanine was affected (FDR = 0.02) by the interaction between genetic strain and DIM. However, complementary tools for time-series analysis (ASCA analysis, MEBA ranking) indicated that alanine and the branched-chain amino acids (BCAA) differed between genetic strains in a lactation-stage dependent manner. Indeed, NZH cows had lower (P-Tukey < 0.05) plasma concentrations of leucine, isoleucine and valine than NAH cows at 21 DIM, probably signaling for greater insulin sensitivity. Metabolic pathway analysis also revealed that, independently of genetic strains, AA metabolism might be structurally involved in homeorhetic changes as 40% (19/46) of metabolic pathways differentially expressed (FDR < 0.05) between 21 and 180 DIM belonged to AA metabolism. © 2021, The Author(s).	
Palabras-Clave: 	Dairy Cows; Early Lactation; Ketosis.	
Categoría del tema: 	L02 Alimentación animal	
URL: 	https://www.nature.com/articles/s41598-021-01564-0.pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (102903-1) - PXI - AP - DD - Scientific Reports/2021 -  -  - DIS