Fecha/hora: 16/06/2024 03:45:51

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	29/05/2020	
Fecha de la última actualización: 	12/02/2021	
Autoria: 	SIGDEL, A.; LIU, L.; ABDOLLAHI-ARPANAHI, R.; AGUILAR, I.; PEÑAGARICANO, F.	
Afiliación: 	ANIL SIGDEL, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; L. LIU, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; ROSTAM ABDOLLAHI-ARPANAHI, Department of Animal Sciences, University of Florida, Gainesville, FL,USA.; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANCISCO PEÑAGARICANO, University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA.	
Título: 	Genetic dissection of reproductive performance of dairy cows under heat stress.	
Año de publicación: 	2020	
Fuente/Imprenta: 	Animal Genetics, 1 August 2020, Volume 51, Issue 4, Pages 511-520. OPEN ACCESS. Doi: https://doi.org/10.1111/age.12943	
ISSN: 	0268-9146	
DOI: 	10.1111/age.12943	
Idioma: 	Inglés	
Notas: 	Article history: Accepted for publication 31 March 2020. / First published:03 May 2020.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Corresponding author: Peñagaricano, F.; Department of Animal Sciences, University of Florida, Gainesville, FL, United States; email:fpenagaricano@ufl.edu	
Contenido: 	ABSTRACT.
Heat stress negatively impacts the reproductive performance of dairy cows. The main objective of this study was to dissect the genetic basis underlying dairy cow fertility under heat stress conditions. Our first goal was to estimate genetic components of cow conception across lactations considering heat stress. Our second goal was to reveal individual genes and functional gene-sets that explain a cow?s ability to conceive under thermal stress. Data consisted of 74 221 insemination records on 13 704 Holstein cows. Multitrait linear repeatability test-day models with random regressions on a function of temperature?humidity index values were used for the analyses. Heritability estimates for cow conception under heat stress were around 2?3%, whereas genetic correlations between general and thermotolerance additive genetic effects were negative and ranged between ?0.35 and ?0.82, indicating an unfavorable relationship between cows? ability to conceive under thermo-neutral vs. thermo-stress conditions. Whole-genome scans identified at least six genomic regions on BTA1, BTA10, BTA11, BTA17, BTA21 and BTA23 associated with conception under thermal stress. These regions harbor candidate genes such as BRWD1, EXD2, ADAM20, EPAS1, TAOK3, and NOS1, which are directly implicated in reproductive functions and cellular response to heat stress. The gene-set enrichment analysis revealed functional terms related to fertilization, developmental biology, heat shock proteins and oxidative stress, among others. Overall, our findings contribute to a better understanding of the genetics underlying the reproductive performance of dairy cattle under heat stress conditions and point out novel genomic strategies for improving thermotolerance and fertility via marker-assisted breeding. 
© 2020 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics	
Palabras-Clave: 	Cow conception rate; Pathway analysis; Thermotolerance; Whole-genome scan.	
Categoría del tema: 	--	
URL: 	https://onlinelibrary.wiley.com/doi/epdf/10.1111/age.12943	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (102300-1) - PXI - AP - DD - PP/ANIMAL GENETICS/2020 -  -  - DIS